Alzheimer disease is a neurodegenerative disorder, age related, progressive, and irreversible; which is marked by severe memory lapses, abnormal behaviour in patients, personality changes and cognitive deterioration. Nevertheless, after a long research and the efforts of pharmaceutical industries, there is still little effective treatment of the Alzheimer disease, and even the existing medications have serious side effects. It is the reason why the interest in the plant-based therapies increases, since natural compounds are typically linked to lower toxicity. Plant-derived cholinesterase inhibitors hold one of the brightest perspectives of slowed down development of Alzheimer disease. Antioxidant and anti-cholinesterase effects of different extracts of Nigella sativa were determined in this study. The antioxidant activity was evaluated in terms of DPPH assay and hydrogen peroxide radical scavenging activity whereas anti-cholinesterase activity was measured in terms of Ellman colorimetric method. The extracts included were most active with the ethanolic extract exhibiting IC50 of 25 µg/ml (DPPH assay) 54 µg/ml (hydrogen peroxide scavenging assay), and 115 µg/ml (AChE inhibition). These findings suggest a great in vitro antioxidant and anti-Alzheimer potential of Nigella sativa extracts showing that their use in in vivo research and eventual formulation as therapeutic agents is feasible.